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The primary outcome, mortality in PARDS patients, was compared between the high and low AVDSF groups and analyzed in a multivariable logistic regression adjusting for inotrope use and PIM 2 score. Correlation between AVDSF and clinical indices of severity were determined. Receiver operating curve and Youden index were used to identify an AVDSF cutoff associated with mortality, which characterized “high or low AVDSF” groups. AVDSF was calculated by the equation: AVDSF = /P aCO 2. Methods: This was a prospective cohort study performed in the setting of a lung protective mechanical ventilation protocol. This study aims to characterize AVDSF in patients with pediatric ARDS (PARDS), to determine its association with clinical outcomes and examine the validity of a previously studied cutoff (AVDSF > 0.25).

4Duke-NUS Medical School, Singapore, Singaporeīackground: Alveolar dead-space fraction (AVDSF), the volume of alveolar gas that does not participate in gas exchange, has been reported to predict mortality and morbidity in adults with acute respiratory distress syndrome (ARDS).

3Center for Quantitative Medicine, Duke-NUS Medical School, Singapore, Singapore.

2Children's Intensive Care Unit, Department of Pediatric Subspecialties, KK Women's and Children's Hospital, Singapore, Singapore.

1Lee Kong Chian School of Medicine, Singapore, Singapore.Sheow Boon Oh 1 Apollo Aguilan 2 Herng Lee Tan 2 Yi-Jyun Ma 2 Rehena Sultana 3 Jan Hau Lee 2,4 Judith Ju Ming Wong 1,4 *